Amspas

A synergistic spasmolytic-analgesic combination where drotaverine (PDE4 inhibitor) relieves smooth muscle spasms while mefenamic acid blocks prostaglandin synthesis. (Brogden RN, 1978) Particularly effective in dysmenorrhea, providing 70% pain reduction within 1 hour. (Budoff PW, 1979) The drotaverine component prevents NSAID-induced spasms. (Tytgat GN, 2003)

Indication

• Primary dysmenorrhea
• IBS (pain-predominant)
• Renal colic
• Biliary dyskinesia
• Endoscopic procedures

Side Effects

• Diarrhea
• Dizziness
• Skin rash
• Methemoglobinemia (overdose)